The Nobel Assembly at Karolinska Institutet
has today decided to award
the 2018 Nobel Prize in Physiology or Medicine
James P. Allison and Tasuku Honjo
for their discovery of cancer therapy by inhibition of negative immune regulation
Cancer kills millions of people every year and is one of humanity’s greatest health challenges. By stimulating the inherent ability of our immune system to attack tumor cells this year’s Nobel Laureates have established an entirely new principle for cancer therapy.
James P. Allison studied a known protein that functions as a brake on the immune system. He realized the potential of releasing the brake and thereby unleashing our immune cells to attack tumors. He then developed this concept into a brand new approach for treating patients.
In parallel, Tasuku Honjo discovered a protein on immune cells and, after careful exploration